The achievement of sustainable development in Kenya has been hindered by the prevalence of HIV. The effects of HIV on sustainable development have been given less academic attention. HIV prevalence prevents people from achieving good health and well-being, which then makes them unable to conduct activities that lead to sustainable economic growth. The paper found that the prevalence of HIV causes economic hardship, destroys human capital development and human resources by reducing life expectancy and increasing mortality rates. It was equally found that the prevalence of HIV undermines social stability and mobility, reduces economic investments, influences food insecurity and makes people vulnerable. The paper found that the prevalence of HIV reduces labor supply and productivity, increases the cost of health services, promote inequality and poverty. The paper found that the prevalence of HIV was caused by the failure to integrate religion, culture and science infrastructure to achieve a holistic treatment acceptance and adherence that would overcome all misconceptions people have towards the disease. The paper found that while science provides effective HIV treatments, religious and cultural perspectives often shape community attitudes toward the disease. It was found that engaging religious and cultural as well as health workers or health advocates can help reduce stigma and promote ART adherence by aligning treatment messages with faith-based principles. The paper found that the integration that incorporates religion, culture, and science into HIV interventions would promote a more inclusive healthcare system that respects diverse beliefs while ensuring evidence-based treatment is accessible and widely accepted. The study was conducted through a qualitative methodology. Data was collected from secondary sources that included published articles, books and occasional papers as well as reports. Collected data was interpreted and analyzed through document analysis techniques.