Platinum- and gold-based drugs on cancer

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Author(s)

Bao Jing Chen, Yoke Kqueen Cheah

Abstract

Cancer remain top health concern around the world. In the war against cancer, drug discovery and development is key focus of main government and non-government organization with the aim of minimizing cancer related harmful outcomes. Emerging of medicinal bioinorganic chemistry has illustrated many innovative metal based drugs that are found to be effective in cancer, with the leading success achieved by cisplatin. Nevertheless, reporting more and more undesirable problems of cisplatin and other platinum anticancer drugs during clinical trial have provided opportunity in searching novel anticancer drugs with distinct mode of action. This review summarise the development and current status of platinum and non-platinum based cancer chemotherapy, represented by gold.

Total Pages: 9

 

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Description

Authors

Bao Jing Chen1, Yoke Kqueen Cheah1,2,3*

1. Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor Darul Ehsan, Malaysia
2. Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor Darul Ehsan, Malaysia
3. Centre for Diagnostic Nuclear Imaging, Universiti Putra Malaysia, Serdang, Selangor Darul Ehsan, Malaysia
*Yoke Kqueen Cheah, Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia; yokekqueen@gmail.com

Abstract

Cancer remain top health concern around the world. In the war against cancer, drug discovery and development is key focus of main government and non-government organization with the aim of minimizing cancer related harmful outcomes. Emerging of medicinal bioinorganic chemistry has illustrated many innovative metal based drugs that are found to be effective in cancer, with the leading success achieved by cisplatin. Nevertheless, reporting more and more undesirable problems of cisplatin and other platinum anticancer drugs during clinical trial have provided opportunity in searching novel anticancer drugs with distinct mode of action. This review summarise the development and current status of platinum and non-platinum based cancer chemotherapy, represented by gold.

Keywords

chemotherapy; platinum; cisplatin; gold; mechanism

Article Info

Received: 17th November 2016
Accepted: 5th March 2017
Available online: 20th April 2017

Citing this article

Bao JC and Yoke KC. Platinum- and gold-based drugs on cancer. J Transdiscip Biomed 2017; 1(1): X–X.

DOI

http:/doi.org/10.24294/jtb.v1i1.1

Copyright

Copyright © 2017 by author(s) and EnPress Publisher LLC. This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).

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