Published Articles

By: Editorial Office

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By: Yuka Hirakawa, Aika Okuno, Daisaku Kimura, Takashi Okuwa, Fukumi Furukawa

Abstract:

Discoid lupus erythematosus (DLE) is an autoimmune disorder that usually occurs on sun exposed areas. We describe a case of a 31-year-old man with reddish-purple, atrophic plaques on the nose and the bilateral cheeks. Histopathologic and d…
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By: Akihiro Aioi

Abstract:

Sirtuins (SIRTs) are initially recognized as NAD+-dependent histone deacetylase. SIRTs attract attention for their role as calorie restriction-induced “longevity proteins” to be expected to extend human life span and to pro…
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By: Wei Boon Yap, Shaktypreya Nadarajah, Nadiah Shidik, Noorjahan Banu Mohammed Alitheen

Abstract: Cancer immunotherapy using cytokines has been sought as an alternative therapeutic approach for treating cancers. Besides remarkable immunoregulatory properties, interleukin (IL)-27 has recently been shown to possess promising anticancer functions; hence,…
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By: Jichang Chen, Xuemei Huang, Yu Zhang, Zheng Nong, Jinjian Fu

Abstract: This study aims to provide a theoretical basis for the development of maternal and child health interventions newborns born in 2016 in Liuzhou of south China’s Guangxi Zhuang Autonomous Region. The condition and the different national basic data of birth …
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By: Ru Wen, Afoma C Umeano

Abstract: Cancer immunotherapy involves the delivery of immunogenic compounds and/or the priming, or induction, of the body’s natural immune system to target cancer. The use of cancer immunotherapy has led to various means of cancer prevention and treatment that ha…
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By: Naoya Mikita, Yutaka Inaba, Takashi Yoshimasu, Nobuo Kanazawa, Fukumi Furukawa

Abstract: Mast cells are involved in many immune reactions and diseases through 1) the expressions of several receptors, 2) productions of various mediators such as histamine, cytokines, and chemokines, 3) direct interactions with immune cells. Besides allergic dis…
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By: Lei Cheng, Xiujuan Cao, Xinchen Yu

Abstract: Environmental pollution caused by industrial and agricultural production has recently become a serious problem. One of the most significant ones is the phenomenon of cyanobacteria bloom caused by eutrophication of water body. Cyanobacterial bloom not only…
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By: Hongliang Wen, Danyang Li, Yuzhan Wu

Abstract: In this study, chemiluminescence immunoassay was used to screen clones of mouse anti-human albumin monoclonal antibody (anti-ALB McAb). The method is simplified as a one-step operation and the experimental parameters are optimized by orthogonal experiment…
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By: Lingyang Cheng, Jianpeng Lv, Yaling Sun

Abstract: MicroRNA (miRNA) is a single-stranded small molecule RNA of non-coding proteins with a length of about 18-24 nucleotides in eukaryotic cells. It is widely found in multicellular organisms and viruses. The miRNA itself is not encoding protein which is main…
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By: Jie Shen, Yusong Liu, Hui Zhang

Abstract: At present, tumors especially malignancies, have become one of the most serious diseases that threaten human health. The use of chemotherapy, radiotherapy, surgery, biotherapy and integrated traditional Chinese and Western medicine is the most effective m…
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By: Xiongtao Zheng, Yafei Yang, Qingyu Chen

Abstract: In this paper, the recent progress of bio-diesel from microalgae in recent years was reviewed. The research history of microbes from microalgae and the breeding and culture of microalgae were studied. Methods and techniques, and compare the microalgae wit…
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By: Qishun Huang, Guanghong Fang, Chunsheng He

Abstract: As a reserve force for a pasture, calf determines the future of the ranch and the future profit of the ranch. The calf’s scientific rearing is the most important part of sustainable development of a ranch. Calf management is a complex and detailed work, b…
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By: Satoshi Nakamizo, Tetsuya Honda, Kenji Kabashima

Abstract: Obesity has become a significant public health problem since it may cause many chronic diseases, including type 2 diabetes, cardiovascular diseases, liver diseases, and some cancers. Recent studies have shown that obesity is a major risk factor for the de…
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By: Rajesh Gupta, Anjali Gupta, Aradhana Singh

Abstract: Developmental malformations of the lung are common but complete agenesis of the lung is quite rare and usually the patients presented are in early childhood; though according to literature, a few cases have come to light even in the adult age group. A 10-…
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By: Lorena Soler Casale, Estela Quintana Livingston, Christa Teves

Abstract: We report a newborn baby boy readmitted to the hospital at 7 days of life with acute dengue due to vertical transmission. A 32-year-old primigravida at 38+ weeks of gestation, with no antenatal care and with severe pre-eclampsia, delivered a normal term b…
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By: Xiaolei Yang, Hai Wang

Abstract: This paper analyzes the imaging and gastrointestinal function of patients with abdominal purpura by searching domestic (China) and foreign literature, combined with clinical experience, and explores the possible characteristics of the disease of the child…
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By: Rajesh Gupta, Aradhana Singh

Abstract: The management of gastroschisis is a challenging problem for pediatric surgeons the world over. There are so many different options ranging from primary closure to staged closure using various kinds of silo. Silos are expensive and not available everywher…
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By: Fatmah Bibi Rajah, Rongxiu Zheng, Yuhui Zhou, Kan Xuan

Abstract: The objectives is to establish a positive correlation between the serology titer of Mycoplasma pneumoniae and the severity of pneumonia, with an emphasis on severity of disease presentation between two different age groups. The research included 110 child…
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By: Takuya Tsunoda, Kazunori Shimada, Naoki Uchida, Shinichi Kobayashi, Yasutsuna Sasaki

Abstract: Recently, the analysis of microbiota has been of interest not only for the clarification of the molecular mechanisms of disease etiology, but also the discovery of novel strategies for treatment. Following the development of “next-generation” sequencing, …
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By: Naoyuki Yoshino, Umid Abidhadjaev

Abstract: This study analyzes the impact of a high-speed rail line on tax revenues and on the economy of affected regions within the country. The economic impact of infrastructure investment can be induced by changes in tax revenues when the infrastructure is in op…
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By: Michael Regan

Abstract: Infrastructure was not a widely researched topic until Aschauer identified the wider economic benefits of investment in the United States during the 1980s. Achauer’s work was a catalyst for further research and debate as researchers tackled weakness in th…
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By: Justin Yifu Lin, Yan Wang

Abstract: Against the backdrop of anti-globalization rhetoric, this paper summarizes our joint book entitled Going Beyond Aid (Lin and Wang 2017) and discusses the prospects for development finance in the broad context of Belt and Road Initiative (BRI). Based on th…
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By: Timo Henckel, Warwick J. McKibbin

Abstract:

Although infrastructure is widely recognized as a key ingredient in a country’s economic success, many issues surrounding infrastructurespending are not well understood. This paper explores six themes: the returns to infrastructure; the role of the pri…
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By: Chao Gao, Yanbing Song, Bing Leng

Abstract: Arterio-venous malformation (AVM) is the most common clinical disease caused by intracranial vascular dysplasia. AVM has particular importance in the clinical setting and is difficult to treat because of its high disability and case fatality rate, as well…
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By: Valerie Cerra, Alfredo Cuevas, Carlos Góes, Izabela Karpowicz, Troy Matheson, Issouf Samake, Svetlana Vtyurina

Abstract: Inadequate infrastructure has been widely viewed as a principal barrier to growth and development in Latin America and the Caribbean. This paper provides a comprehensive overview of infrastructure in the region and highlights key areas in which infrastruc…
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By: Michael Klein

Abstract: The paper lays out basic design options for infrastructure policy. It first sketches mechanisms to assess demand. Then it sets out a hierarchy of issues starting with choice of market structure followed by conduct regulation. Ownership options are largely…
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By: Ajay Chhibber

Abstract: India and China have a competitive yet cooperative relationship. India has not signed on to the Belt and Road Initiative as it has concerns over some aspects of it-especially the China-Pakistan Economic Corridor and the Maritime Silk Road-and has proposed…
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By: Jin Hui, Isabel Rial

Abstract: In this paper, we argue that there is much room for China to strengthen its regulatory framework for public-private partnerships (PPPs). We show that infrastructure projects carried out through local government financing vehicles (LGFVs) are largely unreg…
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By: Túlio César Azevedo Alves, Ana Claudia Oliveira Costa, Alba Benemérita Alves Vilela

Abstract: Back pain secondary to herniated disc is very common throughout the world, leading to frequent absence from work activities, economic and financial losses, in addition to causing major affective-motivational changes. Initial treatment is based on analgesi…
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By: Naoki Kondo, Osamu Tanifuji, Tomoharu Mochizuki, Yosuke Sudo, Naoto Endo

Abstract: A 45-year-old male suffered from persistent swelling and redness, with pain in his left lower leg and ankle. Pathological findings isolated from the ankle joint by arthroscopic synovectomy showed mild synovitis. Initially, this case was diagnosed as chron…
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By: Yung Wing Ho

Abstract: The Editorial Office of Neural Circuits introduces our prestigious Editor-in-Chief, highlighting his endeavours and achievements in the field of neuroscience, and his future plans for Neural Circuits….
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By: Mana Nishiguchi, Fukumi Furukawa, Takaharu Ikeda

Abstract: A 74-year-old woman noticed an edematous erythema on the right upper eyelid two months before her first medical examination, and slight fever, arthralgia and edematous erythema on the forearms and palms around the time of the first medical examination. Sh…
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By: Yu Hu, Lin Lin, Pangen Cui, Xu Yao, Chao Luan, Zhimin Hao, Min Chen

Abstract: Severe psoriasis patients are reported to have a higher risk of liver abnormalities. Treatment option for severe psoriasis patients with liver disorder history remains a great challenge. Hepatic toxicity and long-term safety are the major concerns. Hence …
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By: Junichi Koseki, Atsushi Kaneko, Yosuke Matsubara, Kyoji Sekiguchi, Satomi Ebihara, Setsuya Aiba, Kenshi Yamasaki

Abstract: Prompt elimination of pathogens including bacteria and dead cells prevents the expansion of secondary and prolonged inflammations and tissue damage. Keigairengyoto (KRT) is a traditional Japanese medicine prescribed for dermatoses such as purulent inflamm…
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By: Masahiro Katsuda, Hiroki Yamaue

Abstract: Following numerous unequivocal clinical failures, immunotherapy has become an attractive therapeutic modality. Peptide vaccines are cost-effective compared to other vaccine approaches, and effective epitopes eliciting strong immune response can be selecte…
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By: Yuta Sakurai, Yasunori Umemoto, Takashi Kawasaki, Daisuke Kojima, Tokio Kinoshita, Mami Yamashiro, Motohiko Banno, Hideki Arakawa, Fumihiro Tajima

Abstract: Exercise-induced production of interleukin (IL)-6 results in the expression of chemokine CXC-motif ligand 1 (CXCL1) in mice. Recent studies described the increase in serum IL-6 levels during immersion of subjects in hot water. The present study investigat…
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By: Naotaka Doi, Yumi Nakatani, Yutaka Inaba, Toshikazu Kondo, Fukumi Furukawa, Nobuo Kanazawa

Abstract: The aim of this study is to evaluate the effects of corticosteroid application on each grade of burn, and to clarify the underlying mechanisms of the effects, especially in its acute inflammatory phase. To generate three-graded burn models (epidermal burn…
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By: Judith Anna Seidel, Atsushi Otsuka, Kenji Kabashima

Abstract: Immune checkpoints are essential for preventing immunopathology but can also obstruct anti-tumor immune responses. Recent medical advances in blocking these mechanisms have therefore opened promising avenues in the treatment of cancer. Various blocking a…
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By: Mi Diao, Yi Fan, Tien Foo Sing

Abstract: This study uses the opening of the new Mass Rapid Transit (MRT) in stages between 2010 and 2012 in Singapore as the exogenous event to empirically test the impact of the new Circle Line (CL) on housing wealth. Applying a “differences-in-differences” appro…
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By: Hong Yu

Abstract: Intra-regional trade serves as a key growth engine for East Asian economies. Accompanying the rapid growth of bilateral and intra-regional trade ties, the East Asian economies are becoming increasingly connected and interdependent. Infrastructure connecti…
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By: Juan Carlos Martinez Oliva

Abstract: This paper considers the problems surrounding the implementation of road infrastructure plans in a policy perspective. As the main pillar of regional connectivity, road networks provide the link across national markets, foster strong and sustainable econo…
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By: Abdul Abiad, Renard Teipelke

Abstract: This paper provides a comparative perspective on infrastructure provision in developing Asia’s three largest countries: China, India, and Indonesia. It discusses their achievements and shortfalls in providing network infrastructure (energy, transport, wat…
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By: Der-Horng Lee, Sreyus Palliyani

Abstract: The whole world is in a fuel crisis nearly approaching exhaustion, with climate change knocking at our doorsteps. In the fight against global warming, one of the principle components that demands technocratic attention is Transportation, not just as a sig…
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By: Justin Yifu Lin, Yan Wang

Abstract: The world economy needs a growth-lifting strategy, and infrastructure financing seems to hold the key. Based on the New Structural Economics (Lin, 2010; 2012) we discuss the heterogeneity of capital focusing on the long-term versus short-term orientation …
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By: Tamer Fakhry, Mohamed Shawky

Abstract: Appendicitis is the most common cause of emergency abdominal surgeries in children. Ultrasound (US) has been proven to be a helpful imaging modality in patient evaluation, especially in children suspected of appendicitis. The Alvarado score is a 10-point …
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